VITAMIN D3 ADMINISTRATION'S THERAPEUTIC BENEFITS ON EMBRYO IMPLANTATION

Аннотация

In vitro fertilization (IVF)-embryo transfer (ET) patients who have embryo implantation issues have been clinically tested for a variety of adjuvants. Vitamin D3, a crucial modulator of many physiological processes, has gained attention as a crucial adjuvant for a successful pregnancy because numerous studies have demonstrated a strong correlation between vitamin D deficiency and implantation failure and fetal growth restriction. Nevertheless, vitamin D has been frequently used in various procedures, producing results that are controversial and not reproducible. In this work, we showed that cyclic intrauterine vitamin D3 delivery enhanced angiogenesis and endometrial receptivity, which may be related to a greater recruitment of natural killer cells that reside in the uterus. Specifically, in vitro, cyclic vitamin D3 therapy strengthened the embryo‘s adhesion to endometrial cells, indicating that it may be useful in promoting the first maternal-fetal contacts during the early stages of embryo implantation. Our results indicate that vitamin D3 may be used as a risk-free adjuvant before IVF-ET operations to improve the uterine environment and make it favorable for embryo implantation in women who have experienced repeated implantation failure.